Mohamad Mokadem, MD

Mohamad Mokadem, MD
Associate Professor
Department of Internal Medicine
FOE Diabetes Center


At our laboratory, we specialize in researching the regulation of body weight and metabolism after bariatric surgery in rodents. Our focus is specifically on two types of surgery: Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). We have developed a highly reproducible model of RYGB and SG in mice that accurately mimics the effects of these surgeries on human subjects, including changes in body weight, body composition, fecal calories, glucose homeostasis, and lipid metabolism. By applying this surgical technique to genetic mouse models, we aim to uncover the molecular mechanisms behind these bariatric surgeries.

Recent Publications

Total pancreatectomy with islet cell transplantation vs intrathecal narcotic pump infusion for pain control in chronic pancreatitis.
Mokadem M, Noureddine L, Howard T, McHenry L, Sherman S, Fogel EL, Watkins JL, Lehman GA.
World J Gastroenterol. 2016 Apr 28;22(16):4160-7. doi: 10.3748/wjg.v22.i16.4160.

Leptin Is Required for Glucose Homeostasis after Roux-en-Y Gastric Bypass in Mice.
Mokadem M, Zechner JF, Uchida A, Aguirre V.
PLoS One. 2015 Oct 7;10(10):e0139960. doi: 10.1371/journal.pone.0139960. eCollection 2015.

Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer.
Li H, Chan L, Bartuzi P, Melton SD, Weber A, Ben-Shlomo S, Varol C, Raetz M, Mao X, Starokadomskyy P, van Sommeren S, Mokadem M, Schneider H, Weisberg R, Westra HJ, Esko T, Metspalu A, Kumar V, Faubion WA, Yarovinsky F, Hofker M, Wijmenga C, Kracht M, Franke L, Aguirre V, Weersma RK, Gluck N, van de Sluis B, Burstein E.
Gastroenterology. 2014 Jul;147(1):184-195.e3. doi: 10.1053/j.gastro.2014.04.007. Epub 2014 Apr 13.

Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency.
Mokadem M, Zechner JF, Margolskee RF, Drucker DJ, Aguirre V.
Mol Metab. 2013 Dec 11;3(2):191-201. doi: 10.1016/j.molmet.2013.11.010. eCollection 2014 Apr.

See a list of publications at PubMed